Clinical Research Directory

Inclusion Criteria: * Men and post-menopausal women * Age 30-75 years * BMI 27-40 kg/m2 * Waist circumference \> 102/88 cm for men/women * Weight stable during previous 3 months (± 3 kg) * Willingness to consume the intervention diets * Ability to deal with the monitoring devices * Medications stable for the previous 14 days * Signed informed consent Exclusion Criteria: * Cardiovascular events (myocardial infarction or stroke) during the previous 6 months * Diagnosis of diabetes (any type) or use of any drug who can interfere with glucose homeostasis (i.e., metformin, incretin analogues, SGLT-2 inhibitors) * History of stomach or gastrointestinal conditions (inflammatory bowel disease, Crohn's disease, malabsorption, etc.) * Colostomy, bowel resection, bariatric surgery or other major gastrointestinal surgery * Renal or liver failure (creatinine \<1.7 mg/dl and alanine aminotransferase/aspartate aminotransferase \< 2 times than normal values, respectively) * Anemia (hemoglobin below the age and sex specific normal reference ranges at screening) * Blood donation (or participation in a clinical study with blood sampling) within 30 days prior to inclusion * Having been treated with antibiotics within the past 3 months or planning to undergo treatment during the study period. * Habitual use of probiotic/prebiotic supplements or foods enriched in probiotics * Celiac disease * Vegan/vegetarian diet (or a diet incompatible with protocol diets) * Intense physical activity regimen (\> 7 h/week of moderate intensity or \> 3 h/week of high intensity) * History of drug or alcohol abuse * Not able to understand written and spoken Swedish * Any other reason for lack of suitability for participation in the trial, as judged by the principal investor or co-principal investigator