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RECRUITING
NCT06897475
PHASE2

A Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide

Sponsor: Eli Lilly and Company

View on ClinicalTrials.gov

Summary

The purpose of this study is to measure the change in hemoglobin A1c (HbA1c) with LY3457263 compared with placebo in participants with type 2 diabetes who are not at HbA1c goal when treated with a stable dose of semaglutide or tirzepatide. Participation in the study will last about 9 months.

Official title: A Parallel-Group Treatment, Phase 2, Double-Blind Study of Once-Weekly Subcutaneous LY3457263 Compared to Placebo in Participants With Type 2 Diabetes Mellitus on a Stable Dose of Semaglutide or Tirzepatide Who Failed to Achieve HbA1c Goal

Key Details

Gender

All

Age Range

18 Years - 75 Years

Study Type

INTERVENTIONAL

Enrollment

240

Start Date

2025-03-28

Completion Date

2027-01

Last Updated

2026-03-02

Healthy Volunteers

No

Conditions

Interventions

DRUG

LY3457263

Administered SC

DRUG

Placebo

Administered SC

Locations (56)

Helios Clinical Research - Phoenix

Phoenix, Arizona, United States

Wolverine Clinical Trials

Santa Ana, California, United States

Renstar Medical Research

Ocala, Florida, United States

Oviedo Medical Research

Oviedo, Florida, United States

Balanced Life Health Care Solutions/SKYCRNG

Lawrenceville, Georgia, United States

Rophe Adult and Pediatric Medicine/SKYCRNG

Union City, Georgia, United States

Elite Clinical Trials

Rexburg, Idaho, United States

Investigators Research Group

Brownsburg, Indiana, United States

Richmond University Medical Center

Staten Island, New York, United States

Southgate Medical Group

West Seneca, New York, United States

Lucas Research, Inc.

Morehead City, North Carolina, United States

Shelby Clinical Research

Shelby, North Carolina, United States

Providence Health Partners-Center for Clinical Research

Dayton, Ohio, United States

Alliance for Multispecialty Research, LLC

Norman, Oklahoma, United States

Juno Research

Houston, Texas, United States

Southern Endocrinology Associates

Mesquite, Texas, United States

Texas Diabetes & Endocrinology, P.A.

Round Rock, Texas, United States

Consano Clinical Research, LLC

Shavano Park, Texas, United States

Texas Valley Clinical Research

Weslaco, Texas, United States

Eastside Research Associates

Redmond, Washington, United States

Centricity Research Brampton Endocrinology

Brampton, Canada

Ecogene-21

Chicoutimi, Canada

Viacar Recherche Clinique

Greenfield Park, Canada

Winterberry Research Inc.

Hamilton, Canada

G A Research Associates

Moncton, Canada

Private Practice - Dr. James Cha

Oshawa, Canada

Bluewater Clinical Research Group Inc.

Sarnia, Canada

Maple Leaf Research

Toronto, Canada

Diabetes Heart Research Centre

Toronto, Canada

Fadia El Boreky Medicine

Waterloo, Canada

InnoDiab Forschung Gmbh

Essen, Germany

Velocity Clinical Research, Leipzig

Leipzig, Germany

Gemeinschaftspraxis Dr. Taeschner/Dr. Bonigut

Leipzig, Germany

Institut für Diabetesforschung GmbH Münster

Münster, Germany

RED-Institut GmbH

Oldenburg, Germany

Legeartis - Poradnie Specjalistyczne

Bialystok, Poland

Centrum Badan Klinicznych PI-House sp. z o.o.

Gdansk, Poland

Medyczne Centrum Diabetologiczno Endokrynologiczno Metaboliczne DIAB-ENDO-MET

Krakow, Poland

Centrum Terapii Wspolczesnej J. M. Jasnorzewska Spolka Komandytowo-Akcyjna

Lodz, Poland

Ekamed

Lublin, Poland

Private Practice - Dr. Robert Witek

Tarnów, Poland

NBR Polska

Warsaw, Poland

Szpital Czerniakowski

Warsaw, Poland

4 Wojskowy Szpital Kliniczny z Polikliniką SPZOZ

Wroclaw, Poland

Centro de Endocrinologia Alcantara Gonzalez

Bayamón, Puerto Rico

Mgcendo Llc

San Juan, Puerto Rico

FutureMeds - Birmingham

Birmingham, United Kingdom

Layton Medical Centre

Blackpool, United Kingdom

Southmead Hospital

Bristol, United Kingdom

FutureMeds - Liverpool

Bromborough, United Kingdom

Futuremeds-Newcastle

Newcastle, United Kingdom

Newquay Health Centre

Newquay, United Kingdom

George Eliot Hospital

Nuneaton, United Kingdom

The Adam Practice

Poole, United Kingdom

Clifton Medical Centre

Rotherham, United Kingdom

Rame Group Practice

Torpoint, United Kingdom