Clinical Research Directory

Inclusion criteria: * Age at least 18 years old at time of signing the informed consent * Biological child of at least one parent who directly survived/escaped a genocide * Meets diagnostic criteria for a depressive or anxiety disorder * Capable of providing informed consent and complying with study procedures * Currently using or agreeing to use adequate contraceptive methods. * Fluent in speaking and reading English * Able to swallow pills * Agrees to have study visits recorded with audio and video * Able to provide a contact person who can be reached by investigators in the event of the participant becoming unwell or unreachable * Agrees to inform the investigators within 48 hours of any medical conditions and procedures * Agrees to release of outside medical and psychiatric records * Must not participate in any other interventional clinical trials for the duration of the study. * Must commit to medication dosing, therapy, and all study procedures. Exclusion Criteria: * Not able to give adequate informed consent. * Was directly exposed to or survived a genocide. * Has a history of any medical condition, or any significant clinical finding on screening tests, that could make receiving psilocybin harmful. * Has acute, severe or unstable medical illness. * Has a history of stroke or Transient Ischemic Attack (TIA). * Has a history of psychiatric hospitalization within the last 6 months. * Current serious suicide risk. * Unable or unwilling to safely taper off prohibited psychiatric medications. * Abusing alcohol or other substances. * Has used psychedelics within 3 months of enrollment. * Are pregnant or nursing or able to become pregnant and are not practicing an effective means of contraception.