Clinical Research Directory
Browse clinical research sites, groups, and studies.
Direct Comparison of Altered States of Consciousness Induced by LSD, Psilocybin, and DMT in Healthy Participants
Sponsor: University Hospital, Basel, Switzerland
Summary
The primary objective of this study is to determine whether equivalent moderately high doses of LSD, psilocybin, and DMT produce qualitatively similar peak effects when the effect duration is standardized with ketanserin. A DMT infusion mimicking oral LSD and psilocybin administrations will be tested, as well as intravenously administered ketanserin.
Official title: Direct Comparison of Altered States of Consciousness Induced by LSD, Psilocybin, and DMT in a Randomized, Placebo-controlled, Cross-over Trial in Healthy Participants (LPD-Study)
Key Details
Gender
All
Age Range
25 Years - Any
Study Type
INTERVENTIONAL
Enrollment
24
Start Date
2025-04-01
Completion Date
2026-08-01
Last Updated
2025-03-27
Healthy Volunteers
Yes
Conditions
Interventions
LSD
A moderate to high oral dose of 150 µg LSD will be administered followed by 20 mg intravenous ketanserin after 3 h
Psilocybin
A moderate to high oral dose of 30 mg psilocybin will be administered followed by 20 mg intravenous ketanserin after 3 h
DMT
A moderate to high, dose-escalating, intravenous infusion up to 2 mg/min DMT will be administered followed by 20 mg intravenous ketanserin after 3 h
Placebo
An oral and an intravenous placebo will be administered followed by 20 mg intravenous ketanserin after 3 h
Locations (1)
University Hospital
Basel, Switzerland