Clinical Research Directory

Inclusion Criteria: Primary liver cancer (hepatocellular carcinoma or intrahepatic cholangiocarcinoma) Signed informed consent Patient eligible to start first-line systemic therapy Patient eligible for surgical resection Exclusion Criteria: Concurrent conditions with a life expectancy of less than 12 months Autoimmune or chronic inflammatory diseases Substance abuse dependency Other active extrahepatic malignancies or those treated within the last 3 years, except for the following exceptions: Tumors resected with curative intent and with no evidence of disease recurrence for \>3 years prior to signing the informed consent, considered at low risk of recurrence Adequately resected non-melanoma skin cancers or lentigo maligna with no evidence of metastasis Adequately treated carcinoma in situ of the cervix with no evidence of recurrence Prostatic intraepithelial neoplasia with no evidence of infiltrative disease Adequately treated non-invasive papillary urothelial tumors or urothelial carcinoma in situ HIV infection Lack of patient cooperation or failure to sign the informed consent