Clinical Research Directory

Inclusion Criteria: 1. Female patients with ages ranging from 25 to 75 years. 2. Patients with operable breast cancer (Stage I, II and IIIa). 3. Patients with moderate to large /ptotic breasts. Exclusion Criteria: 1. Patients with a contraindication to breast conservative surgery: 1. Multi-centric disease that can't be incorporated by local excision through a single incision that achieves adequate safety margin and satisfactory cosmetic results. 2. inflammatory carcinoma. 3. Contraindications to postoperative radiation e.g. pregnancy, pre-existing lung disease with reduced diffusing capacity and pulmonary TB. 4. diffuse suspicious malignant micro-calcification on mammography. 5. inability to attain negative surgical margins. 6. cardiomyopathy 7. connective tissue disorders with significant vasculitis. 2. Previous chest wall or breast radiation. 3. Patients' refusal participation.