Inclusion Criteria:
1. Age≥18 years old, male or female;
2. Subjects with relapsed/refractory SLE:
1. Subjects must be diagnosed with SLE according to the 2019 European League Against Rheumatism (EULAR) / American College of Rheumatology (ACR) classification criteria, or the 2012 Systemic Lupus International Collaborating Clinics (SLICC) criteria; the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) score ≥8, with a British Isles Lupus Assessment Group 2004 (BILAG-2004) activity score of A in ≥1 organ at screening, or a BILAG-2004 activity score of B in ≥2 organs.
2. Subjects with lupus nephritis (LN) must be diagnosed with active, biopsy-confirmed lupus nephritis of type III, IV, or V, or type III/IV combined with type V according to the 2018 International Society of Nephrology/Renal Pathology Society (ISN/RPS) criteria; the SLEDAI-2000(SLEDAI-2K) score ≥8;
3. Regular treatment with glucocorticoids and at least two immunosuppressants，immunomodulators, antimalarials, or biologics for at least 3 months, but withpoorly-controlled symptoms or intolerance to treatment.
3. Disease-related pathogenic antibody positive: anti-nuclear antibody (ANA) positive and/or anti-dsDNA positive and/or anti-Smith positive.
4. After signing the informed consent form, subjects and their partners must be willing to use effective and reliable method of contraception, devices or medicines, within one year post Eque-cel infusion (excluding contraception safety periods).
5. Subjects must provide written informed consent before the study begin.
Exclusion Criteria:
1. Disease involved the nervous system with a BILAG-2004 activity score of Class A.
2. History of solid organ transplantation.
3. History of autologous or allogeneic stem cell transplantation.
4. History of prior cell therapy or treatment of BCMA-targeted drug.
5. Known history of primary immunodeficiency (innate or acquired). 6）Concomitant other autoimmune diseases that may interfere with the study evaluation.
7\) Subjects who have received the following drugs/non-drug treatment:
1. Subjects who have used therapeutic doses of corticosteroids (defined as \>20 mg/day of prednisone or equivalent) within 1 week prior to enrollment. Corticosteroids must be tapered gradually according to clinical circumstances (e.g., duration and dose of treatment, severity of disease progression, and patient condition) before discontinuation，until reaching the allowable dose range specified in the protocol. Physiological replacement therapy, topical use, and inhaled corticosteroids are permitted.
2. Subjects who have used immunosuppressants other than corticosteroids within 1 week prior to enrollment.
3. Subjects who received biologic therapies or JAK/BTK/TYK inhibitors within 2 months prior to cell infusion, including but not limited to rituximab, belimumab, or baricitinib.
4. Subjects who underwent plasmapheresis or double filtration within 1 week prior to enrollment.
5. Subjects who received investigational drugs from another interventional clinical trial within 1 month before signing the informed consent form (ICF).
6. Subjects who received treatment of the study disease with any unlisted drugs within at least 5 half-lives prior to cell infusion.
8)Major operation or surgical treatment caused by any reason that occurred or was planned within 4 weeks before enrollment or within 12 weeks after cell infusion.
9)History of psychoactive drug abuse and failed to withdraw, or have a history of psychiatric disorders.
10)Subjects have uncontrolled active fungal, viral, bacterial, or other infections (with persistent infection-related signs/symptoms that have not improvedafter appropriate anti-infective therapy) or infections requiring intravenous anti-infective therapy.
11)Positive for hepatitis B surface antigen (HBsAg) or hepatitis B core antibody (HBcAb) with abnormal peripheral blood hepatitis B virus (HBV) DNA (defined as HBV DNA ≥100 IU/mL or ≥1000 copies/mL or above the normal reference range of the testing center, or positive qualitative HBV DNA); positive for hepatitis C virus (HCV) antibody with detectable peripheral blood HCV RNA (defined as ≥1000 IU/mL); positive for human immunodeficiency virus (HIV) antibody; positive for cytomegalovirus (CMV) DNA (defined as ≥1000 IU/mL); or positive for Treponema pallidum-specific antibody with positive rapid plasma reagin (RPR) test.
12)Blood tests: Absolute neutrophil count \< 1×10\^9 /L, or Absolute lymphocyte count \< 0.3×10 \^ 9 /L, or hemoglobin \<60 g/L。 13)Subjects with serious cardiac disease: including but not limited to unstable angina and/or myocardial infarction within 12 months before screening, any congestive heart failure (New York Heart Association\[NYHA\] classification ≥Grade III), and a history of severe arrhythmias; or left ventricular ejection fraction (LVEF) \<45%.
14)Subjects with severe asthma or chronic obstructive pulmonary disease (COPD). Mild or moderate asthma or COPD under stable treatment may be considered with approval from the investigator and sponsor; orarterial oxygen saturation \<91% at rest.
15）Subjects have a significant risk of severe bleeding assessed by investigator.
16\) Subjects have a severe hepatic insufficiency assessed by investigator. 17) History of severe renal disease; or an estimated glomerular filtration rate (eGFR) \<30 mL/min/1.73m² calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula.
18\) History of acute cerebrovascular events, including transient ischemic attack or stroke, within 6 months prior to enrollment.
19\) Any severe and/or uncontrolled comorbid conditions that, in the investigator's opinion, may interfere with the study evaluation.
20\) Diagnosis of malignancy within 5 years prior to screening, except for cured cervical carcinoma in situ, basal cell or squamous cell skin cancer, localized prostate cancer after radical surgery, ductal carcinoma in situ of the breast after radical surgery, or papillary thyroid carcinoma.
21\) Known history of severe allergy to any component of the eque-cel injection. 22）Pregnant or lactating women. 23) Subjects with other conditions adjudicated by the investigator as unsuitable for enrollment.
