Clinical Research Directory

Inclusion Criteria: 1. Age between 18 to 55 years. 2. Body mass index (BMI) of 19.0 to 28.0 kg/m2 (inclusive). 3. Agreed to take effective contraceptive measures during and 3 months after the last dose of the study period. 4. Understand in detail the content, procedure and possible adverse effects of the trial, and voluntarily sign the written informed consent form (ICF). Exclusion Criteria: 1. Diseases with abnormal clinical manifestations that occurred before screening or are currently occurring and need to be excluded. 2. Vital signs, physical examination, 12-lead electrocardiogram,or laboratory examination deemed clinically significant by the investigator . 3. Subjects with positive tests for infectious diseases. 4. Female who are pregnant or breastfeeding. 5. Unable to tolerate venipunctures or have a history of fainting needles and blood. 6. Historic abuse of alcoholic beverages 7. Smoke ≥5 cigarettes per day within 3 months prior to the study 8. History of drug abuse. 9. Other reasons that the investigator consider it inappropriate to participate in the trial.