Clinical Research Directory

Inclusion Criteria: * Healthy males or females aged 18 to 60 years, inclusive, at the time of informed consent. (Part A only). * Males or females aged 18 to 72 years, inclusive, at the time of informed consent (Part B only). * Body mass index (BMI) \>= 18 and \<= 32 kg/m2 and body weight \>50 kg (Part A only). * Body mass index (BMI) \>=18 and \<=35 kg/m2 and body weight \>50 kg (Part B only). * Triplicate 12-lead electrocardiogram (ECG) after \>5 minutes resting without clinically significant findings at screening and Day -1. * Mean sitting systolic blood pressure (SBP) of \>=130 and \<160 mm Hg (Part B only). Exclusion Criteria: * History of hypotension or orthostatic hypotension. * History of syncope within 1 year. * SBP \<90 mmHg or DBP \<60 mm Hg at screening (Part A only). * Clinical laboratory findings outside of range are deemed clinically significant by the investigator at screening. * Any liver function panel analyte value \> 1.2 ×upper limits of normal (ULN) at screening.