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Remineralization Efficacy of Moringa Oleifera Varnish Vs MI Varnish in Initial Carious Lesions Over 6 Months Follow Up: a Randomized Controlled Clinical Trial
Sponsor: Cairo University
Summary
This randomized clinical trial aimed to test the remineralization effect of laboratory prepared Moringa Oleifera based varnish compared to MI varnish (CPP-ACP) on incipient carious lesions. The study could include any of the following participants: age: 25-35 years, males or females, presentation with at least one active WSLs on the study teeth at the start of the study, good oral hygiene, co-operative patients approving to participate in the trial, have sufficient cognitive ability to understand consent procedures. The main question it aims to answer is in patients with initial caries lesions will Moringa Oleifera varnish have same remineralization efficacy as MI Varnish after 6 months follow up? MI varnish will be used as a comparator as it has been shown in many studies to be superior to fluoride varnish with NaF alone in arresting early caries lesions. The active ingredient, CPP-ACP can slowly release, localize and stabilize amorphous calcium, phosphate, and fluoride on the enamel surface which aids in deep mineralization of white spot lesions.
Key Details
Gender
All
Age Range
25 Years - 35 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2025-05-01
Completion Date
2026-01-01
Last Updated
2025-04-01
Healthy Volunteers
Yes
Interventions
Moringa Oleifera
Moring Oleifera Varnish application Using a disposable bond brush, the varnish will be painted on the diagnosed surfaces, then the patient will be instructed to avoid brushing or flossing and to avoid hard and sticky food or any products that may contain alcohol (oral rinses, beverages, etc.) for the next 4 hours after application.
Varnish
MI Varnish application The varnish will be applied on the clean surfaces according to manufacturer instructions as follows: 1. The foil cover of the MI Varnish unit dosage bottle will be peeled-off and MI Varnish will be stirred with the disposable brush before application. 2. The surfaces will be covered with a thin uniform layer using a disposable bond brush to avoid clumping. 3. The area will be allowed to become wet to ensure the setting of the varnish.
Locations (1)
Hend Taha Hanafi Mahmoud
Cairo, Cairo Governorate, Egypt