Clinical Research Directory

Inclusion Criteria: * • Patients with a gestational age of ≥32 and \<37 weeks at birth on LMP. * Diagnosis of apnea of prematurity (AOP) established as per operational definition within the first 10 days of life. * Either male or female patients Exclusion Criteria: * • Patients diagnosed with Hydrops fetalis (evaluated through medical record). * Patients presenting with major congenital or chromosomal anomalies such as anencephaly, spina bifida, congenital heart defects (e.g., tetralogy of Fallot, transposition of the great arteries), or chromosomal disorders (e.g., trisomy 18, Turner syndrome). * Presence of a confirmed sepsis through blood culture. * Presence of a significant underlying neurological disorder evaluated by history and medical records that could contribute to apnea (e.g., intraventricular hemorrhage with posthemorrhagic hydrocephalus, hypoxic-ischemic encephalopathy) * Patients who have been previously treated with caffeine or other methylxanthines for apnea.