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Prevalence of Ethnic Neutropenia and Duffy Null Phenotype in Neonates
Sponsor: Kaplan Medical Center
Summary
This is a prospective observational study designed to assess the prevalence of the Duffy null phenotype (associated with ethnic neutropenia) in neonates born at Kaplan Medical Center. Blood samples will be collected from umbilical cords (non-invasively) to evaluate Duffy antigen expression. Data on ethnicity, perinatal factors, and routine blood counts at 9-12 months (when available) will also be collected to correlate phenotype with absolute neutrophil count (ANC).
Official title: The Prevalence of Ethnic Neutropenia in Neonates
Key Details
Gender
All
Age Range
1 Minute - 1 Day
Study Type
OBSERVATIONAL
Enrollment
1000
Start Date
2024-10-08
Completion Date
2027-12-31
Last Updated
2025-04-06
Healthy Volunteers
No
Conditions
Interventions
Cord blood
Cord blood samples will be collected during routine G6PD testing. An additional 3 mL will be obtained non-invasively from the umbilical cord to determine the expression of Duffy antigens using serologic gel testing.
Locations (1)
Kaplan Medical Center
Rehovot, Israel, Israel