Clinical Research Directory

Inclusion Criteria: * Adults who report a stool frequency of ≤ 1 per day. * Able to provide written informed consent in English. * Willingness to consume 1 supplement (12 g of yeast mannans or control) daily for 28 days. * Willingness to maintain their usual diet and physical activity patterns throughout the study and refrain from the consumption of any yeast-based foods (e.g. Marmite or Vegemite) or yeast extract supplements. * Willing to comply with study procedures, including stool and urine colle Exclusion Criteria: * Stool frequency of \< 3 per week * Yeast allergy * Vegan dietary pattern * Self-reported kidney disease * Elite athletes or long-distance runners * Use of antibiotic drugs within 1 month of screening * Current use of laxatives or antidiarrheal medications * Use of other investigational products within 3 months of the screening * Previously or currently being treated for intestinal diseases or conditions, including irritable bowel disease (i.e., IBS-D or IBS-mixed), Crohn's disease, ulcerative colitis, celiac disease, or gastrointestinal cancer. * Previous gastrointestinal surgery (e.g., gastric bypass, fundoplication, bowel resection). * Current cancer treatment. * Currently pregnant.