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Acupoint Application With Herbal Fumigation and Wash for Preventing Diarrhea-induced Perianal Infection in Allo-HSCT Patients
Sponsor: Ruijin Hospital
Summary
The goal of this clinical trial is to evaluate whether the combination of herbal fumigation and acupoint application can effectively prevent diarrhea in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT).The main questions it aims to answer are: Does the combination of herbal fumigation and acupoint application reduce the incidence of diarrhea in allo-HSCT patients? Does this intervention improve patients' quality of life and reduce the risk of perianal infections? Researchers will compare the intervention group (herbal fumigation + acupoint application) to the control group (povidone-iodine warm water fumigation) to determine the effectiveness of the TCM-based approach in preventing diarrhea and related complications. Participants will: Receive either herbal fumigation and acupoint application or povidone-iodine warm water fumigation twice daily, starting from 24h before transplant conditioning until 30 days post-transplantation (Day +30). Undergo daily monitoring of perianal and local skin conditions, as well as diarrhea symptoms, by trained professionals. This study aims to provide evidence for a non-invasive, low-risk TCM approach to improving outcomes for allo-HSCT patients.
Official title: Acupoint Application Combined With Herbal Fumigation and Wash for Preventing Diarrhea-induced Perianal Infection in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation:A Single-Center, Randomized, Controlled, Open-Label Clinical Study
Key Details
Gender
All
Age Range
14 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
180
Start Date
2025-03-18
Completion Date
2026-03-30
Last Updated
2025-04-04
Healthy Volunteers
No
Interventions
Intervention Group
Starting 24 hours before pre-treatment, you will receive herbal fumigation of the perianal area twice daily (morning and afternoon), with each session lasting 5 minutes. Additionally, starting 30 minutes after each meal, acupoint application will be performed on five acupoints: Shenque (CV8), Tianshu (ST25), and bilateral Zusanli (ST36). The application will last 4 hours per day.
control group
Starting 24 hours before pre-treatment, you will receive povidone-iodine warm water fumigation of the perianal area twice daily (morning and afternoon), with each session lasting 15 minutes.
Locations (1)
Ruijin hospital
Shanghai, Shanghai Municipality, China