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FET in Adenomyosis
Sponsor: Indira IVF Hospital Pvt Ltd
Summary
Purpose of the Study: To compare the effectiveness of GnRH agonist downregulation alone versus GnRH agonist combined with letrozole in improving pregnancy outcomes in women with adenomyosis undergoing frozen embryo transfer (FET). Research Question: Is the combined use of GnRH agonist and letrozole more effective than GnRH agonist downregulation alone in achieving better ongoing pregnancy rates in adenomyosis cases undergoing FET? Hypothesis: Null Hypothesis (H₀): The combined use of GnRH agonist and letrozole is not more effective than GnRH agonist downregulation alone in achieving a higher ongoing pregnancy rate in adenomyosis cases undergoing FET. Study Outcomes: Primary Outcome: Ongoing pregnancy rate at 12 weeks of gestation.
Official title: Is GnRH Agonist Plus Letrozole a Better Choice Than GnRH Agonist Alone in Adenomyosis Cases Undergoing Frozen Embryo Transfer?
Key Details
Gender
FEMALE
Age Range
21 Years - 42 Years
Study Type
INTERVENTIONAL
Enrollment
700
Start Date
2026-06-25
Completion Date
2026-12-23
Last Updated
2026-01-26
Healthy Volunteers
No
Conditions
Interventions
GnRH agonist downregulation
Triptorelin Acetate 3.75mg for two consecutive dosage at 30 days interval
GnRH agonist and Letrozole
Triptorelin Acetate 3.75mg for two consecutive dosages at 30 days interval) + Letrozole (5 mg once daily for a total of 21 days during the second depot - letrozole stops when Estrogen priming starts
Locations (1)
Indira IVF Pvt Hospital
Udaipur, Rajasthan, India