Clinical Research Directory

Inclusion Criteria: 1. Age ≥ 18 years; 2. Chest imaging shows mediastinal or hilar lymphadenopathy (short axis ≥10 mm), requiring EBUS-TBNA for definitive diagnosis; 3. EBUS-TBNA can be performed on these lymph nodes, and the specimens obtained from conventional EBUS-TBNA with three needle passes are inadequate (macroscopic visible core \< 30 mm); 4. Willing to participate in this clinical study and sign the informed consent form. Exclusion Criteria: 1. Enlarged lymph nodes are identified as cystic or abscesses; 2. Severe coagulopathy, insufficient anticoagulants/antiplatelets withdraw time or bleeding diathesis (platelets\<50\*109/L, INR\>1.3) that do not meet bronchoscopy requirements; 3. Other contraindications to bronchoscopy or transbronchial biopsy, such as severe cardiopulmonary insufficiency, intolerance to anesthesia, or endoscopic procedures; 4. Patients who have participated in another clinical trial within the past three months; 5. Vulnerable groups, such as pregnant women 6. Any other condition that the investigator considers inappropriate for participation in this study.