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RECRUITING
NCT06914401
NA

Oxygenation Procedure for Obese Patients During Intubation in the Operating Room

Sponsor: Clinique Pasteur

View on ClinicalTrials.gov

Summary

Obesity is a risk factor for difficult intubation, with an incidence of up to 15.5%, and difficult mask ventilation. Obesity also reduces the functional residual capacity (FRC) of the lungs, the main reservoir of oxygen during apnoea. Complications associated with induction and intubation in the operating room are more frequent in obese patients. Preoxygenation is a cornerstone in the management of patients at risk of desaturation during induction. The study aims to compare two oxygenation strategies , in obese patients. Oxygenation using a combination of NIV (Non Invasive Ventilation) and HFNO (High Flow Nasal Oxygen) compared with NIV alone in the operating room for induction of general anaesthesia with orotracheal intubation.

Official title: Oxygenation Procedure for Obese Patients Using High Flow Oxygen Therapy Combined With Non-invasive Ventilation During Intubation in the Operating Room: a Randomised Controlled Trial

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

124

Start Date

2025-06-19

Completion Date

2027-03

Last Updated

2026-03-06

Healthy Volunteers

No

Interventions

PROCEDURE

NIV (Non Invasive Ventilation) and HFNO (High Flow Nasal Oxygen)

Combination of two procedures Preoxygenation prior to intubation with NIV (Non Invasive Ventilation) and HFNO (High Flow Nasal Oxygen). During intubation, NIV is stopped and apneic oxygenation is maintained with HFNO

PROCEDURE

NIV (Non Invasive Ventilation)

Single procedure Preoxygenation prior to intubation with NIV (Non Invasive Ventilation).

Locations (5)

CHU Clermont Ferrand - Site Estaing

Clermont-Ferrand, France

Clinique Honoré Cave

Montauban, France

Hôpital Saint Eloi - CHU Montpellier

Montpellier, France

Clinique Mutualiste La Sagesse

Rennes, France

Clinique Pasteur

Toulouse, France