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Hypofractionated Radiosurgery for Localised Prostate Cancer (HYPOSTAT-III)
Sponsor: University Hospital Schleswig-Holstein
Summary
Hypofractionated radiosurgery with 5 fractions is considered standard of care for localized prostate cancer. The investigators initiated this multicenter phase II prospective trial to analyse feasibility (toxicity) of hypofractionated radiosurgery with 3 fractions in patients with localised prostate cancer under the hypothesis that the ratio of patients with late GU and GI toxicity ≥ grade 2 after 1 year amounts to 8.4% and 1.3% and is significant lower than 16.4% and 5.7% currently.
Key Details
Gender
MALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
175
Start Date
2025-07-01
Completion Date
2029-12-31
Last Updated
2025-04-10
Healthy Volunteers
No
Conditions
Interventions
Hypofractionated Radiosurgery
Image-guided stereotactic Linac based RT preferable with "dedicated radiosurgery system" such as CyberKnife
Locations (6)
Saphir Radiosurgery Center Frankfurt am Main
Frankfurt am Main, Hesse, Germany
University Hospital Frankfurt
Frankfurt am Main, Hesse, Germany
European Radiosurgery Center Munich
Munich, Hesse, Germany
Saphir Radiosurgery Center Norther Germany
Kiel, Schleswig-Holstein, Germany
University Medical Center Schleswig-Holstein
Kiel, Schleswig-Holstein, Germany
CyberKnife Centrum Mitteldeutschland
Erfurt, Thuringia, Germany