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The Dragon PLC Trial (DRAGON-PLC)
Sponsor: Maastricht University
Summary
The goal of the DRAGON PLC clinical trial is to determine whether portal vein embolization (PVE) combined with hepatic vein embolization (HVE) improves resectability and overall survival in patients with initially unresectable primary liver cancer compared to standard PVE alone. This trial specifically focuses on patients with hepatocellular carcinoma and cholangiocarcinoma. The main questions this trial aims to answer are whether combined PVE and HVE increases the proportion of patients who become resectable within 3 weeks and improves 5-year overall survival compared to PVE alone by enhancing liver hypertrophy. Participants will: * Undergo either standard PVE or combined PVE and HVE. * Have regular imaging to assess liver resectability. * Be monitored for survival outcomes up to 5 years after intervention.
Official title: The DRAGON PLC Trial - An International Multicenter Randomized Controlled Trial to Compare Combined Portal and Hepatic Vein Embolization (PVE/HVE) With PVE Alone in Primary Liver Cancers.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
358
Start Date
2025-04-01
Completion Date
2032-11-15
Last Updated
2025-05-15
Healthy Volunteers
No
Interventions
Portal Vein Embolization
Description: Portal Vein embolization with Glue by a transhepatic approach
Hepatic Vein Embolization
Hepatic Vein Embolization with Vascular plugs via a transjugular or transfemoral approach in the same session as the PVE procedure
Locations (55)
Yale School of Medicine Hospital
New Haven, Connecticut, United States
Rush University Medical Center
Chicago, Illinois, United States
Mayo Clinic
Rochester, Minnesota, United States
Memorial Sloan Kettering Cancer Center
New York, New York, United States
Cleveland Clinic
Cleveland, Ohio, United States
Monash Medical Center
Melbourne, Australia
Medical University of Vienna
Vienna, Vienna, Austria
Social Center South
Vienna, Vienna, Austria
Erasmus Hospital
Brussels, Brussels Capital, Belgium
UZ Antwerpen
Antwerp, Edegem, Belgium
UZ Gent
Ghent, Gent, Belgium
CHU Liège
Liège, Liège, Belgium
CHU-UCL Namur site Godinne (UCLouvain)
Yvoir, Namen, Belgium
Cliniques Universitaires Saint Luc, UCLouvain
Brussels, Belgium
Jessa Hospital
Hasselt, Belgium
UZ Brussel
Jette, Belgium
AZ Groeninge Hospital Kortrijk
Kortrijk, Belgium
Foothills Medical Center
Calgary, Alberta, Canada
Vancouver General Hospital
Vancouver, British Columbia, Canada
Queen Elizabeth II Health Sciences Center
Halifax, Nova Scotia, Canada
Juravinski Hospital and Cancer Centre
Hamilton, Ontario, Canada
Kingston Health Sciences Centre
Kingston, Ontario, Canada
London Health Sciences Centre
London, Ontario, Canada
St. Joseph's Health Centre
Toronto, Ontario, Canada
Sunnybrook Hospital
Toronto, Ontario, Canada
University Health Network/TGH
Toronto, Ontario, Canada
Centre Hospitalier Universitaire de Sherbrooke
Sherbrooke, Quebec, Canada
Centre Hospitalier de l'Université de Montréal
Montreal, Canada
McGill University Health Centre, Montreal
Montreal, Canada
L'Hopital d'Ottawa
Ottawa, Canada
Royal University Hospital
Saskatoon, Canada
Universitätklinikum Köln
Cologne, Germany
Universitätklinikum Dresden
Dresden, Germany
Universitätklinikum Hannover
Hanover, Germany
Ospedale San Raffaele
Milan, Italy
Maastricht Universitair Medisch Centrum+
Maastricht, Limburg, Netherlands
Amsterdam UMC, location VUMC
Amsterdam, North Holland, Netherlands
Maxima Medisch Centrum
Eindhoven, Netherlands
Universitair Medisch Centrum Groningen
Groningen, Netherlands
Leiden Universitair Medisch Centrum
Leiden, Netherlands
University Hospital Oslo
Oslo, Norway
University Hospital Linköping
Linköping, Sweden
Karolinska University Hospital Stockholm
Stockholm, Sweden
Cantonal Hospital Winterthur
Winterthur, Canton of Zurich, Switzerland
Claraspital Basel
Basel, Switzerland
Universitätsspital Basel
Basel, Switzerland
CHUV - Lausanne University Hospital
Lausanne, Switzerland
Hirslanden Klinik St. Anna
Lucerne, Switzerland
Hirslanden Klinik
Zurich, Switzerland
Belfast Health and Social Care Trust
Belfast, United Kingdom
Queen Elizabeth Hospital
Birmingham, United Kingdom
Aintree University Hospital
Liverpool, United Kingdom
Kings college Hospital
London, United Kingdom
Oxford University Hospitals NHS Foundation Trust
Oxford, United Kingdom
University Hospital Southampton
Southampton, United Kingdom