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RECRUITING
NCT06914908
PHASE2

Long-term Safety and Efficacy Evaluation of Lunsekimig in Adult Participants With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) Who Completed a Previous Lunsekimig CRSwNP Study

Sponsor: Sanofi

View on ClinicalTrials.gov

Summary

This is a single-arm extension study to investigate the long-term safety, tolerability, and efficacy of lunsekimig in adult participants with inadequately controlled CRSwNP who have completed a previous lunsekimig CRSwNP clinical study (also referred to as the parent study ACT18207). The study duration will be up to approximately 56 weeks per participant, 52 weeks of treatment period, and 4 weeks of follow-up.

Official title: A Single-arm Extension Study to Investigate the Long-term Safety, Tolerability, and Efficacy of Lunsekimig in Adult Participants With Inadequately Controlled Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) Who Completed a Previous Lunsekimig CRSwNP Clinical Study

Key Details

Gender

All

Age Range

Any - Any

Study Type

INTERVENTIONAL

Enrollment

64

Start Date

2025-05-12

Completion Date

2031-01-29

Last Updated

2026-03-10

Healthy Volunteers

No

Interventions

DRUG

lunsekimig

Pharmaceutical form: solution for injection Route of administration: subcutaneous

DRUG

Mometasone furoate nasal spray (MFNS)

Pharmaceutical form: Intranasal spray Route of administration: intranasal

Locations (20)

Modena Allergy + Asthma- Site Number : 8400005

La Jolla, California, United States

Treasure Valley Medical Research- Site Number : 8400002

Boise, Idaho, United States

Essential Medical Research- Site Number : 8400020

Tulsa, Oklahoma, United States

McGovern Medical School - UT Physicians Dermatology - Bellaire Station- Site Number : 8400017

Bellaire, Texas, United States

Pharmaceutical Research & Consulting- Site Number : 8400004

Dallas, Texas, United States

ENT Associates of Texas - McKinne- Site Number : 8400014

McKinney, Texas, United States

Alamo ENT Associates- Site Number : 8400001

San Antonio, Texas, United States

Investigational Site Number : 0320002

Rosario, Santa Fe Province, Argentina

Investigational Site Number : 0320001

Buenos Aires, Argentina

Investigational Site Number : 0320003

Mendoza, Argentina

Investigational Site Number : 0560002

Ghent, Belgium

Investigational Site Number : 0560001

Leuven, Belgium

Investigational Site Number : 1000001

Sofia, Bulgaria

Investigational Site Number : 6160004

Poznan, Greater Poland Voivodeship, Poland

Investigational Site Number : 6160002

Krakow, Lesser Poland Voivodeship, Poland

Investigational Site Number : 6160007

Wroclaw, Lower Silesian Voivodeship, Poland

Investigational Site Number : 6160001

Warsaw, Masovian Voivodeship, Poland

Investigational Site Number : 6160003

Katowice, Silesian Voivodeship, Poland

Investigational Site Number : 8260003

Manchester, United Kingdom

Investigational Site Number : 8260001

Newcastle upon Tyne, United Kingdom