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The Role of Maspin in Colorectal Carcinoma, an Immunohistochemical Study
Sponsor: Assiut University
Summary
Colorectal carcinoma (CRC) is a common cancer that arises from genetic and epigenetic changes in colon stem cells. The protein maspin acts as a tumor suppressor, influencing cell adhesion, motility, apoptosis, and angiogenesis. Its role varies by localization within cells; cytoplasmic maspin is associated with low metastatic risk, while nuclear maspin is linked to early recurrence in advanced CRC. Maspin's function can be either tumor-suppressive or oncogenic, depending on its expression and methylation status. Further research is needed to fully understand its prognostic significance in CRC.
Official title: The Role of Maspin (Mammary Serine Protease Inhibitor) in Colorectal Carcinoma, an Immunohistochemical Study
Key Details
Gender
All
Age Range
18 Years - 90 Years
Study Type
OBSERVATIONAL
Enrollment
50
Start Date
2025-08
Completion Date
2029-01
Last Updated
2025-04-08
Healthy Volunteers
No
Conditions
Interventions
maspin ( mammary serine protease inhibitor)
Maspin is an immunohistochemical marker to detect the prognosis of colorectal carcinoma