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Modulation of the Inflammatory Response in Bariatric Surgery
Sponsor: Hospital HM Nou Delfos
Summary
This study will evaluate how different anesthesia techniques affect inflammation after bariatric surgery. Patients will be randomly assigned to receive one of three approaches: opioid-free anesthesia, intravenous anesthesia with opioids, or inhalational anesthesia with opioids. The study will measure blood levels of inflammation-related substances (such as IL-6, CRP, cortisol, ESR , WBC and lactate) at several time points before and after surgery. Heart rate variability will also be monitored as an indicator of the body's stress response. The results may help identify anesthesia strategies that reduce inflammation and improve recovery in patients undergoing bariatric surgery.
Official title: Modulation of the Inflammatory Response to Surgical Trauma: Comparison of Three Anesthetic Techniques in Bariatric Surgery Patients
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
OBSERVATIONAL
Enrollment
90
Start Date
2024-12-02
Completion Date
2025-12-02
Last Updated
2025-04-08
Healthy Volunteers
No
Conditions
Interventions
Opioid-Free Anesthesia (OFA)
Opioid-free anesthesia using a multimodal approach, including dexmedetomidine, lidocaine, ketamine, and magnesium sulfate. No intraoperative opioids are administered.
Opioid-Based Intravenous Anesthesia (OBA-IV)
Standard opioid-based intravenous anesthesia using propofol, remifentanil, and neuromuscular blockade.
Opioid-Based Inhalational Anesthesia (OBA-Inh)
Standard opioid-based inhalational anesthesia using sevoflurane, remifentanil, and neuromuscular blockade.
Locations (1)
Hospital HM Nou Delfos
Barcelona, Barcelona, Spain