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Renal Perfusion and the Development of AKI Following Traumatic Injury
Sponsor: King's College Hospital NHS Trust
Summary
Acute kidney injury (AKI) is a complication of traumatic haemorrhagic shock (THS) and together these conditions increase mortality risk. Although septic shock patients who develop severe AKI are known to develop hypoperfusion of the renal cortex, little is known regarding intra-renal perfusion changes in THS. The aim of the current study is to investigate the effects of THS on renal microcirculatory perfusion.
Official title: Renal Perfusion and the Development of AKI Following Traumatic Injury - A Longitudinal Observational Cohort Study
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
20
Start Date
2024-04-13
Completion Date
2026-07
Last Updated
2025-04-08
Healthy Volunteers
No
Conditions
Interventions
Ultrasound (including contrast enhanced ultrasound)
Ultrasound measures: contrast enhanced ultrasound (CEUS) of the kidney, venous excess ultrasound (VExUS), echocardiography
Sublingual incident dark field videomicroscopy
Sublingual incident dark field (IDF) videomicroscopy
Urinary oxygen tension.
Continuous urinary oxygen tension
Locations (1)
King's College Hospital
London, United Kingdom