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Latency Antibiotics for Previable Rupture Of Membranes Trial
Sponsor: The University of Texas Health Science Center, Houston
Summary
The purpose of this study is to see if the use of prophylactic antibiotics in the expectant management of PPROM less than 22 weeks significantly reduce the rate of delivery within 7 days and to see if the use of prophylactic antibiotics in the expectant management of PPROM between 20 and 22 weeks decrease composite neonatal morbidity.
Official title: Latency Antibiotics for Previable Rupture Of Membranes: LAPROM Trial
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2025-05-01
Completion Date
2027-05-31
Last Updated
2025-04-08
Healthy Volunteers
No
Interventions
Administration of antibiotics prophylactically at the time of membrane rupture
Participants will receive the antibiotic regimen: * Day 1: Oral Azithromycin 1 g once and intravenous Ampicillin 2 g every 6 hours * Day 2: Intravenous Ampicillin 2 g every 6 hours * Days 3-7: Oral Amoxicillin 500 mg every 8 hours
Administration of antibiotics non-prophylactically at 22 weeks
Participants will receive latency antibiotics starting 22 weeks 0 days: * Day 1: Oral Azithromycin 1 g once and intravenous Ampicillin 2 g every 6 hours * Day 2: Intravenous Ampicillin 2 g every 6 hours * Days 3-7: Oral Amoxicillin 500 mg every 8 hours
Locations (1)
The University of Texas Health Science Center at Houston
Houston, Texas, United States