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Post-Extubation High-Flow Nasal Cannula Versus Non-Invasive Ventilation in Type II Respiratory Failure
Sponsor: Benha University
Summary
Acute hypercapnic respiratory failure is characterized by elevated arterial carbon dioxide levels and commonly occurs in patients with chronic respiratory diseases. Patients with type II respiratory failure who experience difficult weaning from invasive mechanical ventilation are at increased risk of post-extubation respiratory failure and reintubation. This randomized clinical trial compared high-flow nasal cannula (HFNC) with non-invasive ventilation (NIV) as respiratory support immediately after extubation in patients aged over 50 years with type II respiratory failure and difficult weaning. The primary objective was to compare reintubation rates at 72 hours and 7 days after extubation.
Official title: Post-Extubation Support Using Nasal Humidified High-Flow Oxygen Versus Non-Invasive Positive Pressure Mechanical Ventilation in Preventing Reintubation Among Patients With Type II Respiratory Failure
Key Details
Gender
All
Age Range
51 Years - Any
Study Type
INTERVENTIONAL
Enrollment
200
Start Date
2025-04-15
Completion Date
2025-11-15
Last Updated
2026-08-25
Healthy Volunteers
No
Interventions
High-Flow Nasal Cannula (HFNC)
Heated and humidified high-flow oxygen was delivered through a nasal cannula immediately after extubation. The device provided adjustable high-flow oxygen to achieve the predefined oxygenation and respiratory-rate targets.
Non-Invasive Ventilation (NIV)
Positive-pressure ventilatory support was delivered immediately after extubation through a conventional oronasal mask using spontaneous/timed (S/T) ventilation, with pressure and inspired oxygen adjusted according to predefined respiratory and gas-exchange targets.
Locations (1)
Benha University Hospital
Banhā, Qalyubia Governorate, Egypt