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"Triple Negative" Adult B-cell Acute Lymphoblastic Leukemia - TRINEG-ALL
Sponsor: Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS
Summary
It is a multicenter, non-interventional, non pharmacological, translational, prospective study. Any decision about drug administration is made by the physician based on his clinical judgment in the context of clinical practice, independently from the decision to include the patient in the study.
Official title: "Triple Negative" Adult B-cell Acute Lymphoblastic Leukemia: Molecular Characterization, Identification and New Stratification
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
60
Start Date
2019-10-23
Completion Date
2026-01
Last Updated
2025-04-09
Healthy Volunteers
No
Conditions
Interventions
"Triple negative" adul B-cell ALL
Samples will be studied with conventional techniques to classify and define properly the disease: morphology, immunophenotype, immunohistochemistry (IHC), conventional Cytogenetic Fluorescence in Situ Hybridization (FISH) will be used when appropriate. ● Isolation of Mononuclear cells The following research methodologies will be applied: * Next Generation Sequencing * Flow cytometry analysis of 3C-up B-ALL top three markers * Gene expression profile analysis * Copy number Alterations analysis * In vitro studies
Locations (3)
Irst Irccs
Meldola, FC, Italy
Ospedale S. Maria delle Croci RAVENNA
Ravenna, RA, Italy
Ospedale Infermi
Rimini, RN, Italy