Clinical Research Directory

Inclusion Criteria: * clinical and radiological features of periodontitis in stage II, III or IV * presence of at least 4 teeth and at least 2 pockets (localized not on the same tooth) with a depth of at least 5 mm in each quadrant Exclusion Criteria: * periodontal treatment within 3 months prior to the study; * antibiotic therapy within 3 months prior to the study; * smoking; presence of systemic diseases affecting periodontal healing, i.e.: immunosuppressive diseases, diabetes, osteoporosis, AIDS, hypertension treated with calcium channel blockers; * use of steroids or other immunosuppressive drugs; * coagulation disorders and use of drugs affecting its mechanisms; * pregnant and breastfeeding women