Clinical Research Directory

Inclusion Criteria: * This study will include patients aged 18 years or older, capable of giving informed consent, presenting with signs of severe acute infection with a risk of developing sepsis at the emergency department or at their primary care physician. Exclusion Criteria: * Patients that are severely ill and require immediate hospitalization Qucik Sepsis Related Organ Failure score (QSOFA) ≥ 1 National Early Warning Score (NEWS) ≥ 5 * Patients that demonstrate confusion, changes in mental state and/or an Mini-Mental State Examination (MMSE) below 26 * Presence of neuropenic fever * Patients currently undergoing immunosuppressive therapy or chemotherapy * Patients with human immunodeficiency virus (HIV) or Acquired Immune Deficiency Syndrome (AIDS) * Suspicion of appendicitis, suspicion of meningitis or meningeal irritation, suspicion of or high risk of developing endocarditis * Complicated operation wounds at the time of screening * Proven pneumonia (CURB 65 score ≥ 1) * Emphysema, Chronic Obstructive Pulmonary Disease (COPD) GOLD \>1 or interstitial lung disease * Patients with oxygen at home \> 2 l/min on a chronic basis (severe underlying lung disease?) * Severe cardiovascular disease including: * Severe heart failure New York Heart Association (NYHA) class \> 1 * Endoprosthesis * Cardiac arrhythmia including atrial fibrillation * Severe heart valve abnormalities * Mechanic valve replacement * Recent acute myocardial infarct or coronarography (less than 1y ago) * Severe peripheral vascular morbidity * Acute chest pain (suspicion of acute coronary pathology) * Suspicion of/chance of septic arthritis