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RECRUITING
NCT06922617
NA

STEPS: Substance Use Trial of E-cigarettes or Pharmacotherapy for Smoking

Sponsor: Medical University of South Carolina

View on ClinicalTrials.gov

Summary

The purpose of this study is to investigate whether non-cigarette tobacco products, namely e-cigarettes (nicotine vapes), can help people who smoke and are in treatment for substance use disorder quit smoking by switching completely to e-cigarettes as compared to FDA-approved medications, namely nicotine replacement therapy in the form of patches and lozenges. Participation will last 6 months and will include five in-person study visits and eleven virtual assessments. Participants will also complete a short daily diary on their phones each day for the first twelve weeks. To qualify, participants must be within 30 days of SUD treatment program admission. This study is being conducted at three outpatient SUD treatment programs across South Carolina. These sites include: 1) the Center for Drug and Alcohol Problems (CDAP) in Charleston, SC, 2) Behavioral Health Services of Pickens County (BHSPC) in Pickens, SC, and 3) Shoreline Behavioral Health Services in Conway, SC. the Medical University of South Carolina in Charleston, SC, Behavioral Health Services in Pickens, SC, and the Medical University of South Carolina in Florence, SC.

Official title: Evaluating a Tobacco Harm Reduction Strategy Among Clients Enrolled in Substance Use Disorder Treatment

Key Details

Gender

All

Age Range

21 Years - Any

Study Type

INTERVENTIONAL

Enrollment

240

Start Date

2025-10-17

Completion Date

2028-09-01

Last Updated

2026-04-03

Healthy Volunteers

Yes

Interventions

BEHAVIORAL

Switching to E-Cigarette

Participants will receive twelve weeks of e-cigarette products with instructions to switch completely at switch date

DRUG

Quitting using Medication

Participants will receive twelve weeks of FDA approved medication, combination NRT, with instructions to quit smoking cigarettes at quit date

BEHAVIORAL

Counseling

Participants will recieve brief weekly counseling to support their quit or switch attempt from cigarettes.

Locations (4)

MUSC Charleston, Center for Drug and Alcohol Problems

Charleston, South Carolina, United States

Shoreline Behavioral Health Services

Conway, South Carolina, United States

Phoenix Center

Greenville, South Carolina, United States

Behavioral Health Services of Pickens County

Pickens, South Carolina, United States