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Between the Belly and the Brain: Distorted Gut-brain Crosstalk in Early-life Adversity
Sponsor: Universitair Ziekenhuis Brussel
Summary
The goal of this observational study is to learn about the effects of early-life adversity (ELA) on the composition of children's microbiome and on their psychosocial functioning. The main questions it aims to answer are: * Do children who have experienced ELA have lower gut microbial diversity and/or an altered gut microbial composition? * Do these microbiome alterations correlate with adverse neurodevelopmental outcomes, including increased levels of stress, social and/or affective problems?
Key Details
Gender
All
Age Range
6 Years - 13 Years
Study Type
OBSERVATIONAL
Enrollment
50
Start Date
2025-05
Completion Date
2026-06
Last Updated
2025-04-10
Healthy Volunteers
No
Conditions
Interventions
Completion of questionnaires; child psychiatric screening; faecal sample analysis
Completion of questionnaires: * FFQ (Food Frequency Questionnaire) - completed by child * KIDSCREEN-10 - completed by child * CRIES-13 (Child Revised Impact of Events Scale) - completed by parents/guardian and child * CTES (Childhood Trust Events Survey) - completed by parents/guardian * RCADS-25 (Revised Children's Anxiety and Depression Scale) - completed by parents/guardian and child Child psychiatric screening using SCID-5-Junior - semi-structured interview conducted with child and parent(s)/guardian Faecal sample analysis: * Beta-diversity (UniFrac and Bray-Curtis distance index) * Firmicutes/Bacteroidetes ratio * Abundance of Prevotella, Lactobacillaceae, Bifidobacteriacae and Lachnospiraceae * Short-chain fatty acid metabolites
Locations (1)
UZ Brussel
Jette, Brussels Capital, Belgium