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RECRUITING

NCT06922994

PHASE2

Statin Effect on Arrhythmogenic Cardiomyopathy Disease Progression (SEARCH)

Sponsor: Centro Cardiologico Monzino

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to learn if Atorvastatin 80 mg is effective to avoid functional right ventricular deterioration in patients affected by Arrhythmogenic Cardiomyopathy. It will also learn about the safety of Atorvastatin 80 mg in this type of patients. The main questions it aims to answer are: 1. Does Atorvastatin 80 mg prevent worstening of the right ventricular functioning? 2. Does Atorvastatin 80 mg prevent the worsening of electric, morphological and biomarkers deterioration? 3. What medical problems do participants have when taking Atorvastatin 80 mg? Researchers will compare Atorvastatin 80 mg to a placebo (a look-alike substance that contains no drug) to see if the drug works to treat Arrhythmogenic Cardiomyopathy. Participants will: 1. Take Atorvastatin 80 mg or a placebo every day for 18 months; 2. Visit the clinic at the enrollment and after 2, 4, 9 and 18 months for checkups and tests; 3. Make a phone call for safety check after 12, 15 and 19 months since the enrollment; 4. Fill out psychological questionnaires

Official title: Statin Effect on Arrhythmogenic Cardiomyopathy Disease Progression

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

102

Start Date

2025-03-31

Completion Date

2026-11-30

Last Updated

2025-07-03

Healthy Volunteers

Conditions

Arrhythmogenic Cardiomyopathy

Interventions

DRUG

Atorvastatin 80 mg/day

Atorvastatin 80mg/day will be administered for 18 months to patients affected by Arrhythmogenic Cardiomyopathy

DRUG

Placebo atorvastatin

One tablet of placebo will be administered for 18 months to patients affected by Arrhythmogenic Cardiomyopathy

Inclusion Criteria: 1. Participant must be at least 18 years of age, at the time of signing the informed consent 2. Participants affected by Arrhythmogenic Cardiomyopathy as defined by task force criteria Exclusion Criteria: 1. Known hypersensitivity to atorvastatin or any of the excipients 2. Moderate or severe liver disease 3. Muscle disease 4. Left ventricular ejection fraction \<35% 5. Congestive heart failure defined by the New York Heart Association (NYHA) as class III or IV. 6. Known cardiomyopathy of other origin: post ischemic, hypertrophic, idiopathic dilated, restrictive; known moderate-to-severe mitral or aortic valvulopathy; pulmonary hypertension; congenital cardiac abnormalities 7. Hypercholesterolemic patients that require the use of lipid lowering drugs. 8. Heart transplantation 9. Estimated life expectancy of less than 2 years 10. Any other medical condition that, in the judgment of the investigator, places the patient at risk or makes the patient unreliable or limits the patient's ability to complete the study 11. Potent CYP3A4 modifiers such as Erythromycin, Clarithromycin Azole antifungals, Protease inhibitors , Gemfibrozil, Ciclosporin, Danazol 12. Fusidic acid (drug for bacterial infections) 13. Hepatitis C antivirals as telaprevir, boceprevir, glecaprevir/pibrentasvir and ledipasvir/sofosbuvir combination 14. Any other lipid lowering drugs such as Statins, Cholesterol absorption inhibitors, Bile acid sequestrants , PCSK9 inhibitors, Adenosine triphosphate-citrate lyase inhibitors , Fibrates, Omega-3 fatty acid ethyl esters 15. Drugs primary indicated as antioxidants 16. Enrollment in another clinical trial or past clinical trial in which an investigational drug was administered within 30 days of Visit 1 or within the 5 half-lives of the investigational drug, whichever is longer. 17. Pregnant or lactating women 18. Women of childbearing age who are not using adequate contraception 19. Known dependency on alcohol - drug abuse. 20. Contraindications to cardiac magnetic resonance

Locations (5)

Fondazione I.R.C.C.S. Policlinico San Matteo

Pavia, PV, Italy

Università Politecnica delle Marche

Ancona, Italy

Centro Cardiologico Monzino IRCSS

Milan, Italy

AORN - Ospedali dei Colli

Naples, Italy

Università degli Studi di Napoli Federico II