Clinical Research Directory

Inclusion Criteria: * Aged 18-75 years; * Patients with indications for colonoscopy and receiving diagnostic colonoscopy, without history of inflammatory bowel disease, colorectal cancer, polypectomy or polyposis syndromes; * Signing the written informed consent; Exclusion Criteria: * Patients with polyposis syndromes (e.g., Peutz-Jeghers syndrome, Cronkhite-Canada syndrome, familial adenomatous polyposis \[FAP\], Lynch syndrome, etc.); * Patients with a history of colorectal polypectomy and pathological diagnosed as adenoma; * Patients with a history of colorectal adenocarcinoma or alarming symptoms; * Patients with a history of inflammatory bowel disease; * Patients with mental illness or severe functional disorder who cannot cooperate with colonoscopy; * Patients with severe cardiopulmonary insufficiency; * Patients with severe coagulation disorders or high bleeding risk (platelets \<50×10⁹/L, INR \>1.5; discontinuation of antithrombotic drugs should follow the 2012 Japanese Guidelines for Gastroenterological Endoscopy in Patients Undergoing Antithrombotic Treatment and the2017 Appendix on Anticoagulants Including Direct Oral Anticoagulants; * Patients with severe electrolyte imbalances; * Patients with acute peritonitis or suspected intestinal perforation; * Patients with toxic megacolon; * Patients with stage 3 or higher hypertension (systolic blood pressure ≥180 mmHg or diastolic blood pressure ≥110 mmHg); * Patients with untreated severe abdominal hernia, intestinal obstruction; * Patients with intestinal strictures of any cause; * Pregnancy and lactation.