Clinical Research Directory

Inclusion Criteria: 1. Age 18-80 years old; 2. Acute ischemic stroke in the posterior circulation, the onset of stroke (or last well known) to the enrollment time within 24 hours; 3. CTA/MRA/DSA confirmed acute basilar artery occlusion; 4. Posterior circulation large infarct: NCCT or DWI showed pc-ASPECTS ≤ 5 points, or pontine midbrain index (PMI) ≥ 3 points; 5. NIHSS score ≥10 points after the onset of the stroke and before enrollment; 6. Able to live independently before the onset of the disease (mRS score ≤2 points); 7. The subject or legal representative is able to sign the informed consent form. Exclusion Criteria: 1. Intracranial hemorrhage (except microhemorrhage) on CT/MRI ; 2. CT/MRI revealed large infarction in the cerebellar hemisphere, with significant mass effect causing compression of the fourth ventricle or brainstem; 3. CT or MRI showed bilateral complete thalamic infarction; 4. Occlusion of anterior and posterior circulation arteries confirmed by CTA/MRA/DSA; 5. The presence of intracranial tumors (except for small meningiomas and cerebral aneurysms with a diameter of \<3mm); 6. Patients with known or highly suspected chronic basilar artery occlusion.; 7. Known severe allergy to contrast agents (except for mild rash); 8. Refractory hypertension (defined as systolic blood pressure \> 185 mmHg or diastolic blood pressure \>110 mmHg) that cannot be controlled by drug therapy; 9. Known pregnant or lactating females, or positive pregnancy test before enrollment; 10. Acute cerebral infarction within 48 hours after cardiovascular and cerebrovascular intervention or major surgery (patients more than 48 hours can be enrolled).