Clinical Research Directory

Inclusion Criteria: * Men and women aged between 20 and 60. * Subjects who are capable of understanding and comply with the study procedures, instructions, and visit schedule. * Subjects who voluntarily decide to participate in the entire course of the trial and provide written consent in the Informed Consent Form. Exclusion Criteria: * Subjects with autoimmune diseases/received immunotherapy and subjects with diabetes mellitus. * Subjects with a history of a hypertrophic scar. * Pregnant or breastfeeding women. * Subjects with untreated epilepsy or underlying porphyria. * When there is an active disease (such as inflammation, infection or tumors) in or near the intended treatment site. * Treatment procedure (e.g., bioresorbable fillers, laser/light therapies, botulinum toxin A injections, facial lift, facial peels, excisional facial surgery, dermal photorejuvenation, oral or maxillofacial surgery, etc.) that may interfere with the treatment area or evaluation within 6 months before screening as determined by the Principal Investigator. * The subject who received soft tissue augmentation at the treatment site at any time before screening as determined by the Principal Investigator. * Subjects with a scar or skin lesion at the treatment site that may interfere with the judgment of the treatment effect. * Subjects who participated in another clinical trial within 60 days before screening or plan to participate in another investigation during this study. * Subjects who plan to receive other wrinkle improvement treatments in the face during this trial. * Subjects who are otherwise determined by the investigator as ineligible for this study.