Clinical Research Directory

Inclusion Criteria: * Age ≥18 years. * Diagnosed with OAG (including exfoliative/pigmentary glaucoma) or OHT. * Gonioscopically visible scleral spur for 360 degrees. * Ability to provide informed consent. * In good health, without prior laser trabeculoplasty, with decision to treat made by an ophthalmologist on the basis of risk profile, patient preference, or both. * Each eye with one of the following qualifying diagnoses (diagnoses may differ between eyes): * High-risk ocular hypertension (OHT): IOP \> 21 mmHg without glaucomatous optic neuropathy (excavation, diffuse or focal thinning or notching of the neuroretinal rim, visible nerve fiber layer defects, or asymmetry of the vertical cup-to-disc ratio of \>0.2 between eyes) \[enrollment of trial participants with High-risk OHT will be capped at 25% of total enrollment\] * Mild primary open-angle glaucoma: glaucomatous optic neuropathy, visual field mean deviation \>-6.0 dB with no points in the central 5° \<15 dB * Moderate primary open-angle glaucoma: glaucomatous optic neuropathy, visual field mean deviation -6.0 dB to \>-12 dB and no more than 1 central 5° point \<15 dB Exclusion Criteria: * Advanced POAG in either eye * Glaucoma other than OAG (including pigmentary and pseudoexfoliation glaucoma) in either eye * Mean IOP \> 35 mmHg at either the screening or baseline visit in either eye * Narrow or closed angle (Shaffer Grade 0, 1, or 2) in either eye * Contraindications to SLT, brimonidine, apraclonidine, or any other study intervention * Any corneal pathology that would preclude accurate assessment of IOP by Goldmann tonometry in either eye * Any intraocular surgical procedure within the past 6 months in either eye * Inability to attend all scheduled study visits * Pregnancy or plan to become pregnant in the next 1 year * Any prior laser trabeculoplasty, including ALT, MLT and SLT.