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Micromanaging Human Sleep Physiology to Treat Sleep Apnea and Other Disorders
Sponsor: Northwestern University
Summary
This study will examine whether a combination of breathing training during wake and targeted reactivation of the training during sleep can induce breathing changes during sleep and subsequent cognitive benefits during wake. Participants with obstructive sleep apnea (who have not yet been treated for sleep apnea) will be recruited. Participants will engage in breath training for one week in their own homes and to record their sleep at home using commercially available mobile devices and subsequently have their sleep monitored for one night of polysomnography recordings plus targeted reactivation in a laboratory setting.
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2025-04-03
Completion Date
2027-04
Last Updated
2025-05-22
Healthy Volunteers
No
Conditions
Interventions
Wake training + TMR
In this within-participant design, all participants will undergo the same intervention of waking training and TMR. Waking training - waking training will associate an auditory cue with a specific learned behavioral response (a tongue protrusion and inhalation) during daily sessions for approximately one week, with home sleep monitoring. TMR - Targeted memory reactivation (TMR) refers to the process of playing learning-associated audio cues quietly during sleep in order to reactivate memories associated with the cue. After completion of waking training, TMR occurs in a laboratory setting, with PSG recording, during a single night.
Locations (1)
Northwestern University
Chicago, Illinois, United States