Clinical Research Directory
Browse clinical research sites, groups, and studies.
Evaluation of Different Medicaments in the Management of Necrotic Primary Molars by Lesion Sterilization and Tissue Repair
Sponsor: Ain Shams University
Summary
Management of non-vital primary molars is challenging due to the natural anatomy of primary teeth, patients' young age, and their behavior toward dental treatment. A simple and effective technique such as Lesion Sterilization and Tissue Repair offers a solution to cases with poor prognosis; however, the medicaments used in this technique have some limitations. This study will evaluate three different medicaments regarding the clinical success, radiographic success, and antibacterial activity.
Official title: Nano-based Medicaments Versus Double Antibiotic Paste in Managing Non-vital Primary Molars: A Randomized Clinical Trial and In-Vitro Study
Key Details
Gender
All
Age Range
4 Years - 8 Years
Study Type
INTERVENTIONAL
Enrollment
108
Start Date
2025-10
Completion Date
2030-08
Last Updated
2025-10-02
Healthy Volunteers
Yes
Interventions
Conventional double antibiotic paste of Metronidazole 500 mg plus Ciprofloxacin 500 mg mixed with propylene glycol
The studied medicament will be placed onto the floor of the pulp chamber.
Double antibiotic paste of Metronidazole and Ciprofloxacin loaded chitosan-coated silver nanoparticles
The studied medicament will be placed onto the floor of the pulp chamber.
chitosan-coated silver nanoparticles
The studied medicament will be placed onto the floor of the pulp chamber.
Locations (1)
Faculty of dentistry Ain shams university
Cairo, Egypt