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Prediction of Detoxification Effect of Fat Emulsion Based on Drug Diffusion Law
Sponsor: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Summary
The goal of this observational study is to establish a predictive model for the clinical use value of fat emulsion as an antidote based on the physical information of fat emulsion on drug diffusion process. The main question it aims to answer is: Observing the effect of fat emulsion on the pharmacokinetic changes of overdose drugs; Observe and evaluate the therapeutic effect of long-chain fat emulsion as an antidote; Participants will have their whole blood samples collected for toxicology testing.
Official title: Prediction of Detoxification Effect of Fat Emulsion Based on Drug Diffusion Law: Clinical Observational Study
Key Details
Gender
All
Age Range
18 Years - 85 Years
Study Type
OBSERVATIONAL
Enrollment
85
Start Date
2024-06-01
Completion Date
2027-05-31
Last Updated
2025-04-13
Healthy Volunteers
No
Conditions
Interventions
Long chain lipid emulsion
For patients presenting with fat soluble drug overdose, administer a weight-based infusion of long-chain lipid emulsion at 0.05 ml/kg/min for 1 hour, not to exceed a total of 250 mL.
Locations (1)
Nanjing Drum Tower Hospital
Nanjing, Jiangsu, China