Clinical Research Directory

Inclusion Criteria: * Age 18 years or older * Individuals eligible for keratoprosthesis surgery, as determined by standard-of-care eligibility criteria * Patients with poor prognosis for corneal transplantation, severe corneal opacity and/or vascularization * Patients with vision worse than 20/200 in the eligible eye, and contralateral eye with vision less than 20/40 * Patients with intact nasal light projection * Willing and able to comply with study plan for the full duration of the study * Willing and able to sign a written informed consent Exclusion Criteria: * Active tuberculosis or untreated latent tuberculosis (e.g., positive interferon-# release assay \[IGRA\] test, such as Quantiferon-gold) * Untreated active hepatitis B or C infection. * Ocular or periocular malignancy and/or infection * Inability to wear contact lens * Pregnancy (positive pregnancy test) or lactating * Participation in another interventional study at the time of screening * Any of the following baseline lab values 1. White blood count \<3500 cells per microliter 2. Platelets \<100,000 per microliter 3. Hematocrit \<30% 4. AST or ALT \>1.5X upper limit normal value * Multiple sclerosis or other demyelinating disease * Severe uncontrolled infection * Moderate to severe heart failure (NYHA class III/IV) * Active malignancy * History of adalimumab intolerance * Pregnancy or lactation * Medical problems or drug or alcohol dependence problems sufficient to prevent adherence to treatment and study procedures. * As judged by the investigator any patients that are questionable for their suitability in the study