Clinical Research Directory

Inclusion Criteria: * Age ≥18 years old * Diagnosed as higher-risk MDS (IPSS intermediate-2/high-risk, or IPSS-R \>3.5, or IPSS-M moderate high-, high-, very high-risk) * Untreated patients * Liver and kidney function less than 2 times of upper limit of normal * ECOG≤2 and expected survival more than 6 months * Informed consent signed Exclusion Criteria: * With active infection * Other malignant tumors * Obvious abnormal liver and kidney function, or abnormal function of other organs * Combined with myelofibrosis * Have undergone bone marrow transplantation * Pregnant or lactating women, or men who have recent reproductive needs * Allergic to azacytidine, Rotercept or excipients * History of polysorbate 80 allergy * Refuse to sign informed consent * Researchers consider it inappropriate to participate in the experiment