Clinical Research Directory

Association of TNFAIP3 With Immune-mediated TTP

Sponsor: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

Summary

This study aims to investigate whether genetic variation in the TNFAIP3 locus is associated with immune-mediated thrombotic thrombocytopenic purpura (iTTP), and whether such association is mediated by decreased expression of A20 (TNFAIP3). The study includes a case-control design to assess genotype-expression association and a cohort study to evaluate clinical outcomes such as disease relapse.

Official title: Association of the TNFAIP3 Genomic Locus With Immune-mediated TTP

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