Clinical Research Directory

Inclusion Criteria: Potential subjects must fulfill all following inclusion criteria: 1. Multivessel coronary artery disease with ACS within 90 days prior to inclusion and successful interventional treatment of the culprit lesion 2. Presence of ≥ 2 de novo non-culprit lesion without hemodynamic relevance in two different coronary vessels (demonstrated either by wire-based or angiography-based coronary physiology) and with MaxLCBI4mm ≥ 325 at baseline IVUS-NIRS 3. Age ≥ 18 years 4. Written informed consent Exclusion Criteria: Patients are not eligible if any of the following applies: 1. Non culprit lesion involving the left main and/or ostial left coronary artery, ostial left circumflex artery or ostial right coronary artery; 2. Non-culprit lesion in a previously stented segment (i.e. within 15 mm from the previously implanted stent); 3. Non-culprit lesion involving small vessel (\<3.0 mm) deemed not suitable to PCI, 4. Non-culprit lesion located in a bypass graft or in a grafted vessel; 5. Severe renal impairment (eGFR\<15ml/min/1.73m2) or patient on dialysis treatment; 6. Known pregnancy r breast-feeding patients; 7. Life expectancy \<2 year due to other severe non-cardiac disease; 8. Legally incompetent to provide informed consent; 9. Partecipation in another clinical study with an investigational product