Clinical Research Directory

Inclusion Criteria: * Meets the diagnostic criteria for low-risk colorectal adenoma. * Has undergone a colonoscopy of adequate quality (adequate bowel preparation, cecal intubation achieved, and withdrawal time ≥6 minutes) and received endoscopic minimally invasive polypectomy. * Within 3 months after adenoma resection. * 18-70 years of age; any sex. * Willing to participate and has voluntarily provided written informed consent. Exclusion Criteria: * Incomplete adenoma resection. * Long-term use of aspirin, folic acid, calcium supplements, vitamin D, or similar agents. * Known hereditary polyposis syndromes (e.g., familial adenomatous polyposis) or hereditary colorectal cancer syndromes (e.g., Lynch syndrome/hereditary nonpolyposis colorectal cancer). * Colonoscopy findings strongly suggestive of inflammatory bowel disease. * History of malignancy within the past 5 years. * Pregnant or breastfeeding women, or participants with pregnancy potential who are planning pregnancy. * Severe cardiovascular or cerebrovascular disease, hepatic or renal insufficiency, or diabetes mellitus. * Severe psychiatric disorders that would preclude cooperation with colonoscopy procedures. * Current condition preventing oral administration of the study drug (e.g., dysphagia, chronic diarrhea, intestinal obstruction). * Participation in another clinical study within the past 3 months or current participation in another clinical study. * Any other condition that, in the investigator's judgment, makes the participant unsuitable for enrollment.