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MitoQ and Ischemic Conditioning To Assess Vascular Health Outcomes
Sponsor: Medical College of Wisconsin
Summary
Stroke survivors have compromised vascular function which may contribute to secondary stroke risk, cardiovascular disease, and may limit their exercise tolerance. Preliminary data shows a single bout of ischemic conditioning or oral ingestion of an over-the-counter antioxidant supplement called MitoQ may improve vascular function and muscle activity in individuals post-stroke.
Official title: MitoQ and Ischemic Conditioning To Assess Vascular Health Outcomes (MITO Study)
Key Details
Gender
All
Age Range
18 Years - 85 Years
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2025-07-22
Completion Date
2026-12-31
Last Updated
2025-09-25
Healthy Volunteers
No
Conditions
Interventions
Ischemic Conditioning
The cuff will be placed around the proximal, non-affected thigh and inflated for 5 minutes in a supine or semi-reclined position, then released for a 5-minute recovery period. Five cycles of inflation and recovery will be performed (45 minutes total).These inflations will be done using a cuff similar to what is used for taking blood pressure.
Antioxidant Supplement
MitoQ is an over the counter supplement that increases delivery to the mitochondria. Similar to studies performed in middle age/older adults and individuals with peripheral arterial disease, we will administer 1 single oral dose of 80mg of MitoQ or a placebo pill. As MitoQ reaches peak concentrations at \~40 to 60 minutes after ingestion, we will wait 45 minutes (time matched to Ischemic conditioning).
Locations (1)
Medical College of Wisconsin
Milwaukee, Wisconsin, United States