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Dexamethasone for Ureteral STent Symptoms (DUSTS)
Sponsor: The Methodist Hospital Research Institute
Summary
The purpose of this study to learn if high-dose dexamethasone, a type of long-acting steroid, works to decrease urinary symptoms and pain after ureteroscopy and stent placement for kidney stones. The main question it aims to answer is: 1\) Does high-dose steroid change the quality of life score on day 2 after surgery Researchers will compare high-dose of dexamethasone (20 mg) to a standard dose of dexamethasone (4 mg) to see if a higher dose of the drug will help with urinary symptoms and pain Participants will: 1. randomly receive 20 mg or 4 mg of dexamethasone (20 mg) at the time of surgery 2. fill out a questionnaire day 1 and day 2 after surgery 3. fill out a medication diary for one week after surgery 4. visit the clinic on day 2 after surgery for checkup 5. visit the clinic on day 4-7 after surgery for check up
Official title: Dexamethasone for Ureteral STent Symptoms (DUSTS): A Randomized, Double-blinded Controlled Study
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
70
Start Date
2026-04
Completion Date
2027-04
Last Updated
2026-03-05
Healthy Volunteers
No
Conditions
Interventions
Dexamethasone Sodium Phosphate Injection 20 mg
dexamethasone 20 mg diluted in 50 mL of normal saline administered by intravenous drip after induction of anesthesia
Dexamethasone Sodium Phosphate Injection 4mg
dexamethasone 4 mg diluted in 50 mL of normal saline administered by intravenous drip after induction of anesthesia
Locations (1)
Houston Methodist Hospital
Houston, Texas, United States