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HOnest Placebos With Explanations: Evaluating Open-Label Placebos for Chronic Pain
Sponsor: Rhode Island Hospital
Summary
The goal of this clinical trial is to examine the effect of rationale condition when taking open-label placebos on pain by 1) comparing each rationale to the no rationale control condition and the no treatment control condition; and 2) comparing the rationale conditions to each other. We also aim to examine the effect of rationale condition on prescription opioid use by 1) comparing each rationale to the no rationale control condition and the no treatment control condition; and 2) comparing the rationale conditions to each other. This study will include patients with chronic low back pain. The main question it aims to answer is: How do rationales influence the effects of open-label placebos? Researchers will compare different rationales given when taking an open-label placebo and a no-treatment group and a no rationale group taking OLPs.
Official title: Optimizing Open Placebos for Chronic Pain Patients
Key Details
Gender
All
Age Range
18 Years - 89 Years
Study Type
INTERVENTIONAL
Enrollment
340
Start Date
2025-03-01
Completion Date
2027-03
Last Updated
2025-04-27
Healthy Volunteers
No
Conditions
Interventions
Open-label Placebo
Open-label placebo pill for 21 days at 2 per day
Standard Rationale
Scientific rationale about the placebo effect
Mindfulness
Mindfulness based rationale
Control Rationale
Basic epidemiological information about chronic pain to achieve structural equivalence for the control groups
Locations (1)
Rhode Island Hospital
Providence, Rhode Island, United States