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Immune-mediated Pathogenic Mechanisms of Neuro-PASC in Veterans
Sponsor: VA Office of Research and Development
Summary
Mental health symptoms, including cognitive impairment ("brain fog"), following COVID-19 are of great concern to Veterans. This research seeks to advance understanding of the long-term effects of COVID-19 on neuropsychiatric and neurological functions, identifying clinically relevant biomarkers and directions for developing and testing therapeutic interventions. To accomplish these objectives the investigators are conducting a longitudinal study at two VA medical centers to: 1) assess and monitor cognitive function and psychiatric symptoms in Veterans post-COVID; 2) evaluate biomarkers of inflammation and signaling pathways associated with viral infection and neuropsychiatric function; and 3) integrate neuropsychiatric and neurological findings with biological data to identify biomarkers and clinical endpoints associated with disease progression or severity, as well as those for promoting brain repair and attenuating those symptoms.
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
OBSERVATIONAL
Enrollment
200
Start Date
2025-02-20
Completion Date
2028-03-31
Last Updated
2026-03-31
Healthy Volunteers
No
Conditions
Locations (2)
VA Portland Health Care System, Portland, OR
Portland, Oregon, United States
James H. Quillen VA Medical Center, Mountain Home, TN
Mountain Home, Tennessee, United States