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RECRUITING
NCT06932237

Immune-mediated Pathogenic Mechanisms of Neuro-PASC in Veterans

Sponsor: VA Office of Research and Development

View on ClinicalTrials.gov

Summary

Mental health symptoms, including cognitive impairment ("brain fog"), following COVID-19 are of great concern to Veterans. This research seeks to advance understanding of the long-term effects of COVID-19 on neuropsychiatric and neurological functions, identifying clinically relevant biomarkers and directions for developing and testing therapeutic interventions. To accomplish these objectives the investigators are conducting a longitudinal study at two VA medical centers to: 1) assess and monitor cognitive function and psychiatric symptoms in Veterans post-COVID; 2) evaluate biomarkers of inflammation and signaling pathways associated with viral infection and neuropsychiatric function; and 3) integrate neuropsychiatric and neurological findings with biological data to identify biomarkers and clinical endpoints associated with disease progression or severity, as well as those for promoting brain repair and attenuating those symptoms.

Key Details

Gender

All

Age Range

18 Years - 80 Years

Study Type

OBSERVATIONAL

Enrollment

200

Start Date

2025-02-20

Completion Date

2028-03-31

Last Updated

2026-03-31

Healthy Volunteers

No

Locations (2)

VA Portland Health Care System, Portland, OR

Portland, Oregon, United States

James H. Quillen VA Medical Center, Mountain Home, TN

Mountain Home, Tennessee, United States