Clinical Research Directory

Inclusion Criteria: * Male or female, aged over 20 and under 80. * Consciousness clear and able to communicate. * Unilateral or bilateral osteoarthritis of the knee with symptoms lasting more than 3 months. * X-ray imaging shows mild to moderate knee osteoarthritis (Kellgren-Lawrence grades 1-3). * Knee joint pain with a Visual Analogue Scale (VAS) score greater than 4. Exclusion Criteria: * Severe knee osteoarthritis (Kellgren-Lawrence grade 4). * Currently systemic infection. * Received hyaluronic acid or corticosteroid intraarticular injections within the past six months, or received NSAIDs or oral corticosteroid treatment within 7 days prior to treatment. * The treated joint has undergone joint replacement surgery or major surgery. * Severe knee deformity or instability. * Known history of cancers, rheumatoid arthritis, platelet dysfunction, thrombocytopenia, hypofibrinogenemia, acute or chronic infectious diseases, chronic liver disease, or poorly controlled cardiovascular disease or diabetes. * Currently receiving anticoagulant therapy. * Long-term or excessive use of aspirin or vitamin E. * History of HIV/AIDS, syphilis, or other legally notifiable infectious diseases. * Pregnant or breastfeeding women, or women and men of childbearing potential who are unable to use effective contraception during the treatment period. * Deemed unsuitable for participation in the trial by the principal investigator. * Unable to sign the informed consent form.