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The Therapeutic Effect of Curcumin in Nanogels Compared to 0.1% FAO in the Management of Oral Lichen Planus
Sponsor: Chulalongkorn University
Summary
This randomized, double-blind clinical trial evaluates the therapeutic effects of curcumin in nanogels compared to 0.1% fluocinolone acetonide oral paste in the management of atrophic-erosive oral lichen planus (OLP). The study aims to determine whether curcumin nanogels, a natural treatment with enhanced bioavailability, are as effective and better tolerated than standard corticosteroid therapy.
Official title: The Therapeutic Effect of Curcumin in Nanogels Compared to 0.1% Fluocinolone Acetonide Oral Paste in the Management of Atrophic-Erosive Oral Lichen Planus
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2025-06-01
Completion Date
2026-06-30
Last Updated
2026-03-06
Healthy Volunteers
No
Conditions
Interventions
Curcumin in Nanogels
Participants will apply curcumin nanogels to affected oral areas three times daily for 4 weeks.
0.1% Fluocinolone Acetonide Oral Paste
Participants will apply 0.1% fluocinolone acetonide oral paste to the affected oral mucosa three times daily for 4 weeks. This corticosteroid paste is the standard treatment for oral lichen planus.
Locations (1)
Faculty of Dentistry, Chulalongkorn University
Bangkok, Thailand