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NOT YET RECRUITING
NCT06933238
PHASE1/PHASE2

Efficacy of Fuzheng Tongfu Jiedu Prescription for Treating Gastrointestinal Dysfunction Associated With Sepsis

Sponsor: Dongzhimen Hospital, Beijing

View on ClinicalTrials.gov

Summary

This study is a single-center, randomized, double-blind, placebo-controlled trial.

Official title: The Clinical Effect and Mechanism of Fuzheng Tongfu Jiedu Prescription Regulating Cell Pyrodeath in the Treatment of Gastrointestinal Dysfunction in Sepsis Based on mtDNA/NLRP3/Caspase-1/GSDMD Signaling Pathway

Key Details

Gender

All

Age Range

50 Years - 90 Years

Study Type

INTERVENTIONAL

Enrollment

70

Start Date

2025-04-25

Completion Date

2026-06-30

Last Updated

2025-04-18

Healthy Volunteers

No

Interventions

DRUG

Fuzheng Tongfu Jiedu prescription (FZTFJD)

Fuzheng Tongfu Jiedu prescription (FZTFJD), a kind of Traditional Chinese medicine (TCM).Conventional Western medical treatment in accordance with the "2021 International Guidelines for the Management of Sepsis and Septic Shock." . This included treatment and resuscitation begin immediately, administering antimicrobials immediately, hemodynamic management, mechanical ventilation, organ support, nutritional support, and prophylaxis for acute ulcers.

DRUG

Placebo

Fuzheng Tongfu Jiedu prescription plaebo. Conventional Western medical treatment in accordance with the "2021 International Guidelines for the Management of Sepsis and Septic Shock." . This included treatment and resuscitation begin immediately, administering antimicrobials immediately, hemodynamic management, mechanical ventilation, organ support, nutritional support, and prophylaxis for acute ulcers.

Locations (1)

Ethics Committee of Dongzhimen Hospital

Beijing, Beijing Municipality, China